Current clinical trials
Breast Cancer Clinical Trials
Neo N - Recruiting
A randomised phase II trial evaluating the efficacy of a nivolumab monotherapy lead in “window” or commencement of nivolumab concurrently with paclitaxel and carboplatin as neoadjuvant therapy in early stage triple negative breast cancers.
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377957&isReview=true
MONARCH 3
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Nonsteroidal Aromatase Inhibitors (Anastrozole or Letrozole) Plus LY2835219, a CDK4/6 Inhibitor, or Placebo in Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative Locoregionally Recurrent or Metastatic Breast Cancer With No Prior Systemic Therapy in This Disease Setting
https://www.clinicaltrials.gov/ct2/show/NCT02246621?term=I3Y-MC-JPBM&rank=1
IMpassion030
A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=7058&isClinicalTrial=True
NATALEE
A trial to evaluate the efficacy and safety of Ribociclib with Endocrine therapy as adjuvant treatment in patients with HR=/HER2-ve early breast cancer
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=18322&isClinicalTrial=True
VIKTORIA 1 - Recruiting
A Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy.
https://clinicaltrials.gov/ct2/show/NCT05501886
Gastrointestinal Cancer Clinical Trials
Challenge
A phase III study of the impact of a physical activity program on disease –free survival in patients with high risk stage II or stage III colon cancer: a randomised controlled trial
http://clinicaltrials.gov/show/NCT00819208
OXTOX - Recruiting
Can Oxaliplatin neurotoxicity be reduced with ibudilast in people with metastatic colorectal cancer – a phase II randomised study
https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12619000566134
Germ Cell Cancer Clinical Trials
P3BEP – Recruiting
Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for participants with intermediate and poor risk metastatic germ cell tumours
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=364125
Haematological Cancer Clinical Trials
Canova
A Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (CANOVA)
https://clinicaltrials.gov/ct2/show/NCT03539744
Melanoma Clinical Trials
HBI-8000-313
This is a phase 3 study to compare the efficacy and safety of HBI-8000 or Placebo combined with nivolumab on patients with unresectable or metastatic melanoma and eligible patients who are not adolescents or patients with new, progressive brain metastasis will be stratified by PD-L1 expression and LDH level.
https://clinicaltrials.gov/ct2/show/NCT04674683
Prostate Cancer Clinical Trials
AnzADAPT - Recruiting
Phase II Randomised Controlled Trial of Patient-specific Adaptive vs. Continuous Abiraterone or eNZalutamide in mCRPC (ANZadapt)
https://www.clinicaltrials.gov/study/NCT05393791
Mic-1 - Recruiting
Phase II Study to Investigate the Ability of Macrophage Inhibitory Cytokine-1 (MIC-1)
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=335301
Enzamet
Randomised phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365575
Enzarad
Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365611
Embark
A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus Leuprolide, Enzalutamide Monotherapy, and Placebo Plus Leuprolide in Men With HighRisk Nonmetastatic Prostate Cancer Progressing After Definitive Therapy
Keynote 199
Study of Pembrolizumab (MK-3475) in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated With Chemotherapy (MK-3475-199/KEYNOTE-199)
https://clinicaltrials.gov/ct2/show/NCT02787005?term=Keynote+199&rank=1
Magnitude
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer (MAGNITUDE)
CheckMate 7DX
A Study of Nivolumab or Placebo in Combination With Docetaxel in Men With Advanced Castration-resistant Prostate Cancer (CheckMate 7DX)
https://clinicaltrials.gov/ct2/show/NCT04100018
CheckMate 650
Study of Nivolumab Plus Ipilimumab, Ipilimumab or Cabazitaxel in Men With Metastatic Castration-Resistant Prostate Cancer (CheckMate 650)
https://clinicaltrials.gov/ct2/show/NCT02985957
LEEP - Recruiting
A phase II randomised controlled trial to establish if LEE0011 (ribociclib) is effective in inhibiting the growth of prostate cancer cells
https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12618000354280
HENGRUI
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer
https://clinicaltrials.gov/ct2/show/NCT04691804
Capitello 280 - Recruiting
A Phase III Double-Blind, Randomised, Placebo-Controlled Study Assessing the Efficacy and Safety of Capivasertib + Docetaxel Versus Placebo + Docetaxel as Treatment for Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
https://clinicaltrials.gov/ct2/show/NCT05348577
Climate - Recruiting
Assessing the Clinical utility of miR-371a-3p as a marker of residual disease in Clinical Stage 1 Testicular Germ Cell Tumour, following orchidectomy.
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=383439&isReview=true
Solid Tumours Clinical Trials
Oric 114-01 - Recruiting
An Open-Label, Phase 1/1b, Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration