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10 Feb 2014

News from the ARI

The Australian Research Institute (ARI) is the research arm of the San established to facilitate, coordinate and fund innovative and developmental research within the Adventist Healthcare setting.


Research studies published by the ARI in 2013 include:


1. Guest J*, Grant R†, Mori T.A, Kroft K. D. Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS ONE (http://dx.plos.org/10.1371/journal.pone.0085335 2014)
Main points: This study has showed for the first time that Free radical damage increases in the brain with age. Higher free radical damage was also associated with alcohol intake and some types of fats

2. Braidy N, Poljak A, Grant R, Jaysena T, Mansour H, Chan-Ling T, Guillemin G, Smythe G, Sachdev, P. Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology (In Press Dec 2013)
Main points
: This study has showed that free radical damage increased in the brain with age and appeared to worsen after middle age. The structures of the brain associated with memory (e.g. hippocampus) were most affected.

3. Pope B*, Hokin B, Grant R. Effect of Maternal Iron Status on the Number of CD34+ Stem Cells Harvested from Umbilical Cord Blood. Transfusion (In press Nov 2013)
Main points:
This study has showed that higher levels of ferritin (and therefore iron) in the mum is llinked to lower cord blood stem cell availability. This has implications for stem cell therapy.

4. Grant R†, Guest J*, Bilgin A, Morris M, Garg M, Pearce R. Suboptimal Omega-3 levels in Australian Adolescents. Int. J. Child Health & Nutrit., 2: 309-315 2013
Main points:
This study has showed that ~60% of adolescents have omega-3 levels in the ‘at risk’ of disease range. Because of its relevance to inflammatory modulation, low levels of omega-3 have been consistently linked to disorders such as depression and cardiovascular disease.

5. Kent L, Morton D, Rankin P, Ward E, Grant R, Gobble J, Diehl H. The effect of a low-fat, plant-based lifestyle intervention (CHIP) on serum HDL levels and the implications for Metabolic Syndrome status - a cohort study. Nutrit & Metab (In press – Sept 2013)
Main points: In this study conducted by Avondale college researchers a new perspective was provided on the role of HDL levels in assessing cardiovascular risk; especially in people following a plant rich diet

6. Braidy N, Lim C.K, Grant R; Brew B.J, Guillemin G.J. Serum Nicotinamide Adenine Dinucleotide Levels Through Disease Course in Multiple Sclerosis. Brain Research Aug 21. pii: S0006-8993(13)01147-5. doi: 10.1016/j.brainres.2013.08.025. [Epub ahead of print 2013]
Main points: This study showed for the first time that decreases in an important molecule NAD+ in multiple sclerosis is linked to the more advanced stages of the disease.

7. Guest J*, Garg M, Bilgin A, Grant R†. Relationship between central and peripheral fatty acids in humans. Lipids in Health and Disease, 12:79 2013
Main points:
This study has looked at the relationship between serum and CSF dietary fatty acids.


Click here for more information on the Australian Research Institute.

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